2012年4月1日零時，武廣、廣深港高鐵廣深段（以下簡稱廣深高鐵）實行新的列車運行圖。按照新的列車運行圖，武廣、廣深高鐵***安排108對動車組，深圳北安排20對直通長沙和武漢的高速動車組。實行新的列車運行圖後，武廣、廣深高鐵***安排108對動車組，其中武廣、廣深間跨線動車組20對；武廣高鐵安排60對；廣深高鐵安排28對。
兩條高鐵開行102對時速300km/h高速動車組，分別為：武漢～深圳北10對，車次以“G10”字開頭，分別為G1001～G1006、G1011～G1024；長沙南～深圳北10對，車次以“G60”開頭，分別為：G6001～G6020；武漢～廣州南40對，車次以“G11”開頭，分別為：G1101～G1180；長沙南～廣州南14對，車次以“G61”開頭，分別為：G6101～G6128；廣州南～深圳北28對，車次以“G62”開頭，分別為：G6201～G6262。
深圳北至武漢直通高速動車組最早車次為G1012次，發車時間為7：00分，到武漢時間為11:40分；最晚車次為G1024次，發車時間為18：01分，到武漢時間為22:48分。
深圳北至長沙南直通高速動車組最早車次為G6002次，發車時間為8：00分，到長沙南時間為11:20分；最晚車次為G6020次，發車時間為20：30分，到長沙南時間為23:48分。
武漢至深圳北直通高速動車組最早車次為G1011次，發車時間為7：26分，到深圳北時間為12:16分；最晚車次為G1023次，發車時間為17：25分，到深圳北時間為22:20分。
長沙南至深圳北直通高速動車組最早車次為G6001次，發車時間為7：00分，到深圳北時間為10:21分；最晚車次為G6019次，發車時間為16：59分，到深圳北時間為20:21分。
為方便旅客上下車，所有直通列車均停省會車站；省會車站停站時間為2～3分鐘，其它車站2分鐘，較之前相對延長。
兩條高鐵分日常、周末、高峰期開行不同對數列車
據廣鐵集團介紹，此次調圖分日常、周末、高峰期分別開行不同對數列車，具體為：
日常開行81對,其中武漢～深圳北10對、武漢～廣州南35對、長沙南～深圳北10對、長沙南～廣州南10對、廣州南～深圳北16對。周末開行86對，在日常基礎上增開長沙南～廣州南5對。高峰期視客流情況安排開行對數。日常為周壹至周四，周末為周五至周日，高峰期為春暑運、黃金周、小長假。 列車時刻表 廣州南-深圳北深圳北-廣州南信息車次發時到時歷時車次發時到時歷時裏程壹等座二等座特等座商務座G62017:027:310:29G10027:007:290:2910299.574.5119.5199.5G63177:077:390:32G60127:137:490:3610299.574.5119.5199.5G62037:178:010:44G29027:207:560:3610299.574.5119.5199.5G62057:228:060:44G727:538:210:2810299.574.5119.5199.5G62077:318:140:43G60148:028:380:3610299.574.5119.5199.5G63017:458:210:36G61428:208:560:3610299.574.5119.5199.5G62118:208:560:36G10048:269:020:3610299.574.5119.5199.5G62138:259:090:44G62028:359:110:3610299.574.5119.5199.5G62158:479:240:37G748:459:210:3610299.574.5119.5199.5----------------------------G62048:569:320:3610299.574.5119.5199.5G63059:009:290:29G10069:2310:000:3710299.574.5119.5199.5G62179:3110:070:36G8189:3210:080:3610299.574.5119.5199.5G60119:4810:240:36----------------------------10299.574.5119.5199.5G62199:5510:380:43----------------------------10299.574.5119.5199.5G632510:1010:460:36G62069:4510:210:3610299.574.5119.5199.5G601310:1810:550:37G62089:5210:280:3610299.574.5119.5199.5G622110:2511:010:36G82210:0010:360:3610299.574.5119.5199.5G601510:4411:210:37G100810:1510:510:3610299.574.5119.5199.5G622310:5211:280:36G621010:2711:030:3610299.574.5119.5199.5----------------------------G621211:0011:500:5010299.574.5119.5199.5G622510:5711:350:38G601611:0711:430:3610299.574.5119.5199.5G622711:2512:010:36G101011:2011:560:3610299.574.5119.5199.5G100111:3512:120:37G8011:2912:050:3610299.574.5119.5199.5G622911:5412:300:36G290411:4812:240:3610299.574.5119.5199.5G423112:0012:370:37----------------------------10299.574.5119.5199.5G100312:1012:460:36G621411:5512:310:3610299.574.5119.5199.5G623112:2012:560:36----------------------------10299.574.5119.5199.5G100512:3113:070:36G601812:0212:380:3610299.574.5119.5199.5G63712:3613:120:36G621612:2112:570:3610299.574.5119.5199.5G7712:4713:170:30G631812:2913:050:3610299.574.5119.5199.5G623312:5213:280:36G103212:3513:110:3610299.574.5119.5199.5G601713:0013:370:37G82612:5013:260:3610299.574.5119.5199.5G623513:2013:560:36G101213:1013:460:3610299.574.5119.5199.5----------------------------G621813:2114:040:4310299.574.5119.5199.5G632113:3014:140:44G630213:2913:580:2910299.574.5119.5199.5G601913:4814:240:36G101413:3414:100:3610299.574.5119.5199.5G290113:5914:290:30G622013:4914:250:3610299.574.5119.5199.5G100714:0514:410:36G7814:0014:300:3010299.574.5119.5199.5G100914:1914:490:30G602014:0514:410:3610299.574.5119.5199.5G623714:2515:010:36----------------------------10299.574.5119.5199.5G631314:3015:060:36G622214:1015:000:5010299.574.5119.5199.5G602114:3615:130:37G622414:2515:080:4310299.574.5119.5199.5G623914:4515:290:44G630614:4215:160:3410299.574.5119.5199.5G101115:1715:530:36G290614:5315:340:4110299.574.5119.5199.5G624115:2216:120:50G600215:0015:290:2910299.574.5119.5199.5G63315:2916:060:37G101615:0815:430:3510299.574.5119.5199.5G291115:4216:190:37----------------------------10299.574.5119.5199.5G630915:5016:26 0:36----------------------------10299.574.5119.5199.5G624315:5616:320:36G101815:1315:490:3610299.574.5119.5199.5----------------------------G622615:2016:030:4310299.574.5119.5199.5----------------------------G602215:3316:090:3610299.574.5119.5199.5G103116:0616:510:45G7615:5016:260:3610299.574.5119.5199.5G624516:2316:590:36----------------------------10299.574.5119.5199.5G101316:3817:070:29G632616:1416:500:3610299.574.5119.5199.5G602316:4517:220:37G102016:2417:000:3610299.574.5119.5199.5G81717:0017:360:36G63416:3217:070:3510299.574.5119.5199.5G632917:1017:460:36G622816:5217:280:3610299.574.5119.5199.5----------------------------G291217:0517:410:3610299.574.5119.5199.5----------------------------G623017:1917:550:3610299.574.5119.5199.5G7117:1717:530:36G602417:3018:000:3010299.574.5119.5199.5G600117:2917:580:29G102217:3618:120:3610299.574.5119.5199.5G624717:4818:240:36G623217:4818:240:3610299.574.5119.5199.5G53118:0018:290:29G623417:5618:390:4310299.574.5119.5199.5G7918:0618:350:29G623618:1318:490:3610299.574.5119.5199.5G101518:2018:570:37G602618:2018:560:3610299.574.5119.5199.5G7318:3919:090:30G63818:3019:060:3610299.574.5119.5199.5G624918:4719:230:36G623818:4419:200:3610299.574.5119.5199.5G101718:5619:390:44G624019:0219:380:3610299.574.5119.5199.5G625119:1019:530:43G624219:1719:530:3610299.574.5119.5199.5G82119:5120:270:36G624419:2920:050:3610299.574.5119.5199.5G101919:5620:320:36G632219:5920:350:3610299.574.5119.5199.5G625320:0820:440:36----------------------------10299.574.5119.5199.5G625520:2020:560:36G624620:1220:480:3610299.574.5119.5199.5G290320:3821:140:36G602820:0620:420:3610299.574.5119.5199.5G625720:4821:260:38G631420:1820:540:3610299.574.5119.5199.5----------------------------G624820:3021:060:3610299.574.5119.5199.5G7521:0421:400:36G625020:5921:350:3610299.574.5119.5199.5G102121:2321:590:36G625221:0921:450:3610299.574.5119.5199.5G290521:3422:110:37G625421:2522:010:3610299.574.5119.5199.5G82521:4322:190:36G625821:3622:120:3610299.574.5119.5199.5G602521:5322:300:37G631021:4222:180:3610299.574.5119.5199.5G602722:1922:550:36G625621:4822:240:3610299.574.5119.5199.5G625922:3023:090:39G626022:1922:550:3610299.574.5119.5199.5G614123:0823:370:29G633023:0323:320:2910299.574.5119.5199.5